Autophagy Dysfunction in Alzheimer's Disease and Dementia

Tadanori Hamano, Tatsuro Mutoh
Elsevier
356 pages
ISBN: 9780323899062
August 2022

This book provides an overview for researchers and clinicians on the mechanisms involved in protein degradation in Alzheimer’s. It discusses the implication of autophagy dysfunction in these diseases and how it causes degenerated proteins, including aggregated tau and aggregated amyloid protein. Other sections explores the possibilities of potential drug development through autophagy modulation, making this a great resource on the study of how autophagy dysfunction has been linked to the accumulation of misfolded proteins that cause death of neurons in Alzheimer’s and other neurodegenerative diseases.