Managing Treatment-Resistant Depression

Road to Novel Therapeutics

Joao Luciano de Quevedo, Patricio Riva-Posse, William Bobo
Elsevier
612 pages
ISBN: 9780128240670
April 2022

This book defines Treatment Resistant Depression (TRD), discussing the clinical and epidemiological predictors, economic burden and neurobiological factors. In addition, staging methods for treatment resistance are fully covered, including serotonin specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, other classes of antidepressants. Evidence supporting the use of psychotherapies and neuromodulation strategies are also reviewed.