An Innovative Approach to Understanding and Treating Cancer: Targeting pH

From Etiopathogenesis to New Therapeutic Avenues

Koltai, Reshkin, Harguindey
Elsevier S&T
574 pages
ISBN-13: 9780128190593
January 2020

An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity.